Our challenge
It might happen from unusual observations
The agent targeting detached cancer cells
Most cancer-related problems are caused by metastasis via attachment-free cell growth and survival. Unfortunately there has been no effective agents preventing or delaying fundamental metastatic processes. We are developing a new therapeutic approach able to affect only metastatic cells growing in attachment-free condition.
Pinpointing cancer's vulnerability under attachment-free condition
Our leading candidate "Drug D" is able to affect only cells growing in attachment-free condition (3D spheroid) while do nothing on the same cells growing in 2D monolayer.
This behavior differentiates from currently available anti-cancer therapeutics including small molecules and ADCs which tend to be more effective in 2D than 3D.
The novel mechanism of action has a potential of overcoming drug resistance encountered with current anti-cancer therapeutics.
Drug D: unique features
Only cytotoxic to cells growing in attachment-free condition
Works for a broad range of cancer cells
No off-target toxicity from "bystander effect"
Potential of overcoming drug resistance